Publication

 
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Corresponding Author

#Principal/Corresponding author

Selected Research

  1. Y Liu, CH Poon, LSR Tse, J Roy, CT So, BCK Tong, KM Yao, GL Tipoe, H Steinbusch, L Aquili, A Kalueff, KH Cheung, ML Fung, LW Lim#. (2025) Homeostatic DNMT3a activity is required to restore hippocampal DNA methylation and cognition in a mouse model of Alzheimer’s disease. Aging and Disease (5-year IF: 7.1; Rank: 6/74, top 7.4% in Geriatrics & Gerontology; In press)

  2. CH Poon, Y Liu, S Pak, RC Zhao, L Aquili, GL Tipoe, GKK Leung, YS Chan, S Yang, ML Fung, EX Wu, LW Lim#. (2023) Prelimbic cortical stimulation with L-methionine enhances cognition through hippocampal DNA methylation and neuroplasticity mechanisms. Aging and Disease 14(1). 112-135. (5-year IF: 7.1; Rank: 6/74, top 7.4% in Geriatrics & Gerontology)

  3. X Wang, ATL Leong, SZK Tan, EC Wong, Y Liu, LW Lim, EX Wu. (2023) fMRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation. Nature Communications 14:2195. (5-year IF: 16.1; Rank: 8/134, top 7.5% in Multidisciplinary Sciences)

  4. WS Yu, ACK Tse, L Guan, JLY Chiu, SZK Tan, S Khairuddin, SK Agadagba, ACY LML Fung, YS Chan, LLH Chan, LW Lim#. (2022) Antidepressant-like effects of transcorneal electrical stimulation in rat models. Brain Stimulation 15(3):843-856. (5-year IF: 8.2; JCI Rank: 16/227, top 8.3% in Clin. Neurol.)

  5. SZK Tan, CH Poon, YS Chan, LW Lim#. (2021) Prelimbic cortical stimulation disrupts fear memory consolidation through ventral hippocampal dopamine D2 receptors. British Journal of Pharmacology 178(17):3587-3601. (5-year IF: 7.4; Rank: 18/354, top 8.5% in Pharmacology & Pharmacy)

Others

  1. LW Lim#, VI Molchanov, OV Volkodav. (2007) Iatrogenic Traumatic Brain Injury: Penetration of Kirschner's knitting needle into the middle cranial cavity. Journal of Craniofacial Surgery 18(3):674-679. (IF: 1)

  2. LW Lim#, Y Temel, V Visser-Vandewalle, H Steinbusch, K Schruers, R Hameleers, G Esquivel, E Griez, A Blokland. (2008) Effect of buspirone on the behavioral regulation of rats in low versus high anxiety conditions. Arzneimittel-Forschung/Drug Research 58 (6):269-276. (IF: 0.7)

  3. LW Lim#, A Blokland, V Visser-Vandewalle, R Vlamings, T Sesia, H Steinbusch, K Schruers, E Griez, Y Temel. (2008) High-frequency stimulation of the dorsolateral periaqueductal gray and ventromedial hypothalamus fails to inhibit panic-like behaviour. Behavioural Brain Research 193:197–203. (IF: 2.6)

  4. LW Lim#, Y Temel, T Sesia, R Vlamings, V Visser-Vandewalle, H Steinbusch, A Blokland. (2008) Buspirone induced acute and chronic changes of neural activation in the periaqueductal gray of rats. Neuroscience 31; 155 (1):164-173. (IF: 2.9)

  5. LW Lim#, A Blokland, V Visser-Vandewalle, H Steinbusch, Y Temel. (2009) The Periaqueductal Gray: From longitudinal columns to defensive behaviour. Journal of Experimental Clinical Medicine 26(1):1-26. (IF: N.A.)

  6. LW Lim#, Y Temel, V Visser-Vandewalle, A Blokland, H Steinbusch. (2009) Fos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter. Journal of Chemical Neuroanatomy 38(2):83-96. (IF: 2.7)  

  7. LW Lim#, OV Volkodav. (2009) Germinal matrix hemorrhage of prematurity: Treatment approaches and outcomes in a single institutional review in the Ukraine. Pediatric Neurosurgery 45:132–140. (IF: 0.7)  

  8. LW Lim#, K Schruers, Y Temel. (2009) Does serotonin 2A receptor gene polymorphism increased the vulnerability to panic attacks? Journal of Experimental Clinical Medicine 27(1):1-3. (IF: N.A.)

  9. LW Lim#, Y Temel. (2010) A theory of the Basal Ganglia and their disorders. R. Miller. Publishers CRC Press, Taylor & Francis Group 2008. Book Review. Journal of Chemical Neuroanatomy 39(4):289. (IF: 2.7)  

  10. A Jahanshahi1, LW Lim1#, Visser-Vandewalle, H Steinbusch, Y Temel. (2010) Buspirone-induced changes in the serotonergic and non-serotonergic cells in the dorsal raphe nucleus of rats. Neuroscience Letters 473:136–140. (IF: 2.5) 

  11. LW Lim#, A Blokland, S Tan, R Vlamings, T Sesia, M Aziz-Mohammadi, V Visser-Vandewalle, H Steinbusch, K Schruers, Y Temel. (2010) Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray. Experimental Neurology 226:293–300. (IF: 4.6)

  12. LW Lim, S Tan, HJ Groenewegen, Y Temel. (2011) Electrical brain stimulation in depression: which target(s)? Biological Psychiatry 69(4): e5-6. (5-year IF: 10.8; Rank: 15/310, top 6.1% in Neuroscience)

  13. LW Lim#, A Blokland, M van Duinen, V Visser-Vandewalle, R Vlamings, S Tan, M Janssen, A Jahanshahi, M Aziz-Mohammadi, HWM Steinbusch, K Schruers, Y Temel. (2011) Increased plasma corticosterone levels after periaqueductal gray stimulation-induced escape reaction or panic attacks in rats. Behavioural Brain Research 218(2):301-7. (IF: 2.6)

  14. Y Temel#, A Jahanshahi, MLF Janssen, J van Overbeeke, L Ackermans, A Leentjens, LW Lim. (2012) Neuromodulation in Psychiatric disorders. International Review of Neurobiology 107:283-314. (Invited Review; IF: 4.3)

  15. Y Temel#, LW Lim. (2012) Neurosurgical treatments of depression. Current Topics in Behavioral Neurosciences 14:327-39. (Invited Review)

  16. Y Temel, A Blokland, LW Lim#. (2012) Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats. Behavioural Brain Research 233(3):322-5. (IF: 2.6)

  17. N Jain1, LW Lim1, TW Ting, B George, E Makeyev, T Thanabalu. (2014) Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology. Experimental Neurology 254:29-40. (IF: 4.6)

  18. D Hestermann, Y Temel, A Blokland, LW Lim#. (2014) Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation. Behavioural Brain Research 279:17-21. (IF: 2.6)

  19. LW Lim#, M Janssen, E Kocabicak, Y Temel. (2015) The antidepressant effects of ventromedial prefrontal cortex stimulation is associated with neural activation in the medial part of the subthalamic nucleus. Behavioural Brain Research 279:17-21. (IF: 2.6)

  20. A Liu, N Jain, A Vyas, LW Lim#. (2015) Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats. eLife 4: e04803. (5-year IF: 7.2; Rank: 8/109, top 6.9% in Biology)

  21. LW Lim#, J Prickaerts, G Huguet, E Kadar, H Hartung, T Sharp, Y Temel#. (2015) Electrical stimulation alleviates depressive-like behaviors of rats: Investigation of brain targets and potential mechanisms. Translational Psychiatry. 5: e535. (5-year IF: 6.3; Rank: 25/276, top 8.9% in Psychiatry) [Featured in international media]

  22. LW Lim1#, S Shrestha1, YZ Or, SZK Tan, HH Chung, Y Sun, CL Lim, S Khairuddin, T Lufkin, VCL Lin#. (2016) Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice. Scientific Reports. 6: 37568. (IF: 3.8)

  23. G Huguet, Y Temel, E Kadar, LW Lim#. (2017) Electrical stimulation normalizes c-Fos expression in the deep cerebellar nuclei of depressive-like rats: Implication of antidepressant activity. Cerebellum 16(2): 398-410. (IF: 2.7)

  24. PS Chong1, CH Poon1, ML Fung, L Guan, H Steinbusch, YS Chan, WL Lim#, LW Lim#. (2019) Distribution of neuronal nitric oxide synthase immunoreactivity in adult male Sprague-Dawley rat brain. Acta Histochemica 121(8):151437. (IF: 2.3)

  25. SZK Tan, V Sheng, YS Chan, LW Lim#. (2019) Eternal sunshine of the neuromodulated mind: Altering fear memories through neuromodulation. Experimental Neurology 314:9-19. (IF: 4.6)

  26. SZK Tan, ML Fung, JH Koh, YS Chan, LW Lim#. (2020) The paradoxical effect of deep brain stimulation on memory. Aging and Disease 11(1):179-190. (5-year IF: 7.1; Rank: 6/74, top 7.4% in Geriatrics & Gerontology)

  27. KY Wong, J Roy, ML Fung, BC Heng, C Zhang, LW Lim#. (2020) Relationships between mitochondrial dysfunction and neurotransmission failure in Alzheimer’s disease. Aging and Disease 11(5):1291-1316. (5-year IF: 7.1; Rank: 6/74, top 7.4% in Geriatrics & Gerontology)

  28. CH Poon1, Y Wang1, ML Fung, C Zhang, LW Lim#. (2020) Rodent models of amyloid-beta feature of Alzheimer’s disease: Development and potential treatment implications. Aging and Disease 11(5):1235-1259. (5-year IF: 7.1; Rank: 6/74, top 7.4% in Geriatrics & Gerontology)

  29. S Khairuddin, L Aquili, BC Heng, TLC Hoo, KH Wong, LW Lim#. (2020) Dysregulation of the orexinergic system: A potential neuropeptide target in depression. Neuroscience and Biobehavioral Reviews 111:57-68. (5-year IF: 8.7; Rank: 3/55, top 4.8% in Behavioral Sciences)

  30. CH Poon, YS Chan, ML Fung, LW Lim#. (2020) Memory and neuromodulation: a perspective of DNA methylation. Neuroscience and Biobehavioral Reviews 111:57-68. (5-year IF: 8.7; Rank: 3/55, top 4.8% in Behavioral Sciences)

  31. SY Lew, SL Teoh, SH Lim, LW Lim#, KH Wong#. (2020) Discovering the potentials of medicinal mushrooms in combating depression - A review. Mini-Reviews in Medicinal Chemistry 20(15):1518-1531. (IF: 3.3)

  32. PS Chong, ML Fung, KH Wong, LW Lim#. (2020) Therapeutic potential of Hericium erinaceus for depressive disorder. International Journal of Molecular Sciences 21(1):163. (5-year IF: 5.6)

  33. L Guan1, WS Yu1, S Shrestha, YZ Or, T Lufkin, YS Chan, VCL Lin#, LW Lim#. (2020) TTC9A deficiency induces estradiol-mediated changes in hippocampus and amygdala neuroplasticity-related gene expressions in female mice. Brain Research Bulletin 157:162-168. (IF: 3.5)

  34. CH Poon, LS Tse, LW Lim#. (2020) DNA methylation in the pathology of Alzheimer’s disease: From gene to cognition. Annals of the New York Academy of Sciences 1475(1):15-33. (5-year IF: 6.3)

  35. M Mihardja1, J Roy1, KY Wong1, L Aquili, BC Heng, YS Chan, ML Fung, LW Lim#. (2020) Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer’s disease. Annals of the New York Academy of Sciences 1478(1):43-62. (5-year IF: 6.3)

  36. LF Hiew1, S Khairuddin1, L Aquili, J Koh, ML Fung, WL Lim, LW Lim#. (2020) Behavioural responses of anxiety in aversive and non-aversive conditions between young and aged Sprague-Dawley rats. Behavioural Brain Research 385:112559. (IF: 2.6)

  37. S Khairuddin1, FY Ngo1, WL Lim, NA Khan, L Aquili, ML Fung, YS Chan, Y Temel, LW Lim#. (2020) A decade of progress in deep brain stimulation of the subcallosal cingulate for the treatment of depression. Journal of Clinical Medicine 9(10):3260. (5-year IF: 4)

  38. SZK Tan, LW Lim#. (2020) A practical approach to the ethical use of memory modulating technologies. BMC Medical Ethics 21(1):89. (IF: 3)

  39. SZK Tan, R Du, JAU Perucho, SS Chopra, V Vardhanabhuti#, LW Lim#. (2020) Dropout in neural networks simulates the paradoxical effects of deep brain stimulation on memory. Frontiers in Aging Neuroscience 12:273. (5-year IF: 4.6)

  40. PS Chong1, S Khairuddin1, ACK Tse, LF Hiew, CL Lau, GL Tipoe, ML Fung, KH Wong#, LW Lim#. (2020) Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia. Scientific Reports. 10(1):14945. (IF: 3.8)

  41. SZK Tan, Y Temel, AY Chan, ATC Mok, JAU Perucho, A Blokland, L Aquili, WL Lim#, LW Lim#. (2020) Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation-induced anticipatory fear in a rat model. Brain Structure and Function 225(7):1957-1966. (5-year IF: 2.9, Rank: 2/22, top 2.5% in Anatomy & Morphology)

  42. SZK Tan, J Neoh, A Lawrence, EX Wu, LW Lim#. (2020) Prelimbic cortical stimulation improves spatial memory through distinct patterns of hippocampal gene expression in aged rats. Neurotherapeutics 17:2054–2068. (5-year IF: 6.9; Rank: 31/354, top 8.6% in Pharmacology & Pharmacy)

  43. LW Lim, L Aquili#. (2021) GABA supplementation negatively affects cognitive flexibility independent of tyrosine. Journal of Clinical Medicine 10(9):1807. (5-year IF: 4)  

  44. CH Poon, BC Heng, LW Lim#. (2021) New insights on brain-derived neurotrophic factor epigenetics: from depression to memory extinction. Annals of the New York Academy of Sciences 1484(1):9-31. (5-year IF: 6.3)

  45. LF Hiew, CH Poon, H You, LW Lim#. (2021) Tgf‐β/smad signalling in neurogenesis: Implications for neuropsychiatric diseases. Cells 10(6):1382. (Invited Review; 5-year IF: 6)

  46. J Roy, KC Tsui, J Ng, ML Fung, LW Lim#. (2021) Regulation of Melatonin and neurotransmission in Alzheimer’s disease. International Journal of Molecular Sciences 22(13):6841. (5-year IF: 5.6)

  47. MWL Phang, SY Lew, I Chung, WKS Lim, LW Lim#, KH Wong#. (2021) Therapeutic roles of natural remedies in combating hereditary ataxia: A systematic review. Chinese Medicine 16(1):15. (5-year IF: 5.5; Rank: 3/43, top 5.8% in Integrative & Complementary Medicine)

  48. SZK Tan#, LW Lim#. (2021) An existentialist approach to authentic science. IBRO Neuroscience Reports 11:52-55. (IF: 2)

  49. YY Yow#, TK Goh, KY Nyiew, LW Lim#, SM Phang, SH Lim, S Ratnayeke, KH Wong#. (2021) Therapeutic potential of complementary and alternative medicines in peripheral nerve regeneration: A systematic review. Cells. 10:2194 (Invited Review; 5-year IF: 6)

  50. WS Yu, SH Kwon, Agadagba SK, Chan LLH, KH Wong, LW Lim#. (2021) Neuroprotective effects and therapeutic potential of transcorneal electrical stimulation for depression. Cells 10(9):2492. (Invited Review; 5-year IF: 6)

  51. HJ Chan, Yanshree, J Roy, GL Tipoe, ML Fung, LW Lim#. (2021) Therapeutic potential of human stem cell implantation in Alzheimer’s disease. International Journal of Molecular Sciences 22(18):10151. (5-year IF: 5.6)

  52. CH Poon, KC Tsui, SC Chau, PS Chong, SWY Lui, L Aquili, KH Wong, LW Lim#. (2021) Functional roles of neuronal nitric oxide synthase in neurodegenerative diseases and mood disorders. Current Alzheimer Research 18(10):831-840. (Invited Review; IF: 1.8)

  53. CH Poon, SZK Tan, V Sheng, S Wang, L Aquili, LW Lim#. (2021) A brief comparative look at experimental memory editing techniques for cognitive dysfunction. Current Alzheimer Research 18(10):841-848. (Invited Review; 5-year IF: IF: 1.8)

  54. PS Chong1, CH Poon1, J Roy, KC Tsui, SY Lew, M Phang, RJY Tan, PG Cheng, ML Fung, KH Wong#, LW Lim#. (2021) Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression. Chinese Medicine 16:132. (5-year IF: 5.5; Rank: 3/43, top 5.8% in Integrative & Complementary Medicine)

  55. SZK Tan, RC Zhao, S Chakrabarti, I Stambler, K Jin, LW Lim#. (2021) Interdisciplinary research in Alzheimer’s disease and the roles international societies can play. Aging and Disease 12(1):36-41. (5-year IF: 7.1; Rank: 6/74, top 7.4% in Geriatrics & Gerontology)

  56. MS Uddin, WS Yu, LW Lim#. (2021) Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease. Ageing Research Reviews 70:101417. (5-year IF: 13; Rank: 3/74, top 3.4% in Geriatrics & Gerontology)

  57. MF Hossain, N Wang, R Chen, J Roy, MG Uddin, Z Li, LW Lim#, YQ Song#. (2021) Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer’s disease neuropathology. Ageing Research Reviews 67:101304. (5-year IF: 13; Rank: 3/74, top 3.4% in Geriatrics & Gerontology)

  58. J Roy1, KY Wong1, L Aquili, MS Uddin, GL Tipoe, BC Heng, KH Wong, ML Fung, LW Lim#. (2022) Role of melatonin in Alzheimer’s disease: From preclinical studies to novel melatonin-based therapies. Frontiers in Neuroendocrinology 65:100986. (5-year IF: 8.1; Rank: 30/310, top 9.5% in Neurosciences)

  59. MS Uddin, LW Lim#. (2022) Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications. Ageing Research Reviews 78:101622. (5-year IF: 13; Rank: 3/74, top 3.4% in Geriatrics & Gerontology)

  60. KH Wong#, HY Nam, SY Lew, M Naidu, P David, TA Kamalden, SNHH Haji, LW Lim# (2022) Discovering the potential of natural antioxidants in age-related macular degeneration: A review. Pharmaceuticals 15:101. (5-year IF: 4.6)

  61. T Strekalova, Y Liu, D Kiselev, S Khairuddin, JLY Chiu, J Lam, YS Chan, D Pavlov, A Proshin, KP Lesch, DC Anthony, LW Lim#. (2022) Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives. Psychopharmacology 239(3):663-693. (IF: 3.5)

  62. E Svirin, E Veniaminova, J Costa-Nunes, A Gorlova, A Umriukihn, AV Kalueff, A Proshin, DC Anthony, A Nedorubov, ACK Tse, S Walitza, LW Lim#, KP Lesch, T Strekalova#. (2022) Predation stress causes excessive aggression in female mice with partial genetic inactivation of tryptophan hydroxylase-2: evidence for altered myelination-related processes. Cells 11(6):1036. (5-year IF: 6)

  63. SY Lew, MWL Phang, PS Chong, J Roy, CH Poon, WS Yu, LW Lim#, KH Wong#. (2022) Discovery of therapeutics targeting oxidative stress in autosomal recessive cerebellar ataxia: A systematic review. Pharmaceuticals 15(6):764. (5-year IF: 4.6)

  64. AD Flores1, WS Yu1, ML Fung, LW Lim#. (2022) Neuromodulation and hippocampal neurogenesis in depression: A scoping review. Brain Research Bulletin 188:92-107. (IF: 3.5)

  65. WS Yu, L Guan, SZK Tan, S Shrestha, YZ Or, T Lufkin, VCL Lin#, LW Lim#. (2022) Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice. Iranian Journal of Basic Medical Sciences 25:698-703. (IF: 2.1)

  66. Yanshree1, WS Yu1, ML Fung, CW Lee, LW Lim#, KH Wong#. (2022) The monkey head mushroom and memory enhancement in Alzheimer’s disease. Cells 11(15):2284. (5-year IF: 6)

  67. WS Yu, L Aquili, KH Wong, ACY Lo, LLH Chan, YS Chan#, LW Lim#. (2022) Transcorneal electrical stimulation enhances cognitive functions in aged and 5xFAD mouse models. Annals of the New York Academy of Sciences 1515:249-265. (5-year IF: 6.3; Rank: 24/134, top 17.5% in Multidisciplinary Sciences)

  68. KC Tsui1, J Roy1, SC Chau, KH Wong, L Shi, CH Poon, Y Wang, T Strekalova, L Aquili, RCC Chang, ML Fung#, Y Song#, LW Lim#. (2022) Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5XFAD mouse model of Alzheimer’s disease. Frontiers in Aging Neuroscience 14:964336. (5-year IF: 4.6)

  69. CH Poon, STN Wong, J Roy, Y Wong, HHW Chan, H Steinbusch, A Blokland, Y Temel, L Aquili, LW Lim#. (2023) Sex differences between neuronal loss and the early onset of amyloid deposits and behavioral consequences in 5xFAD transgenic mouse as a model for Alzheimer’s disease. Cells 12(5):780. (5-year IF: 6)

  70. SC Chau1, PS Chong1, H Jin, KC Tsui, S Khairuddin, ACK Tse, SY Lew, GL Tipoe, CW Lee, ML Fung, KH Wong#, LW Lim#. (2023) Hericium erinaceus promotes anti-inflammatory effects and regulation of metabolites in an animal model of cerebellar ataxia. International Journal of Molecular Sciences 24(7):6089. (5-year IF: 5.6)

  71. SY Lew, NS Mohd Hisam, MWL Phang, SNS Abdul Rahman, SH Lim, MA Kamaruzzaman, SC Chau, KC Tsui, LW Lim#, KH Wong#. (2023) Adenosine improves mitochondrial function and biogenesis against l-buthionine sulfoximine-induced oxidative stress in Friedreich’s ataxia fibroblasts. Biology 12(4):559. (IF: 3.6)

  72. S Khairuddin, WL Lim, L Aquili, KC Tsui, ACK Tse, S Jayalath, R Varma, T Sharp, A Benazzouz, H Steinbusch, A Blokland, Y Temel, LW Lim#. (2023) Prelimbic cortical stimulation induces antidepressant-like activities through dopaminergic-dependent and -independent mechanisms in rats. Cells 12(11):1449. (5-year IF: 6)

  73. S Li, CH Poon, Z Zhang, M Yue, R Chen, Y Zhang, Md Hossain, Y Pan, J Zhao, L Rong, LW Chu, YF Shea, E Rogaeva, J Tu, P George-Hyslop, LW Lim#, Y Song#. (2023) MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer’s disease. CNS Neuroscience & Therapeutics 29(7):1848-1864. (5-year IF: 5.9; Rank: 50/354, top 14% in Pharmacology & Pharmacy)

  74. T Strekalova, O Moskvin, AY Jain, N Gorbunov, A Gorlova, D Sadovnik, A Umriukhin, R Cespuglio, WS Yu, ACK Tse, AV Kalueff, KP Lesch#, LW Lim#. (2023) Molecular signature of excessive female aggression: study of stressed mice with genetic inactivation of neuronal serotonin synthesis. Journal of Neural Transmission 130(9):1113-1132. (IF: 3.2)

  75. J Koh, J Liu, CH Poon, J Kang, MS Basabrain, LW Lim#, C Zhang#. (2024) Transplantation of neural progenitor cells derived from stem cells from apical papilla through small-molecule induction in a rat model of sciatic nerve injury. Tissue Engineering and Regenerative Medicine 21(6):867-879. (IF: 4.4)

  76. J Zhang, KC Tsui, HY Lee, L Aquili, KH Wong, E Kocabicak, Y Temel, Z Lu, ML Fung, A Kalueff, LW Lim#. (2025) Data mining approach on melatonin treatment in Alzheimer’s disease: New gene targets MMP2 and NR3C1. International Journal of Molecular Sciences 26(1):338. (IF: 4.9)

  77. H Jin, L Aquili, BC Heng, T Strekalova, ML Fung, GL Tipoe, E Kocabicak, A Blokland, Y Temel, Z Lu, A Kalueff, KH Wong, LW Lim#. (2025) Ganoderma lucidum: a novel alternative therapeutic approach for depression. Food Reviews International (5-year IF: 6.7; Rank: 16/114, top 13% in Nutrition & Dietetics)

  78. Y Liu, L Aquili, KH Wong, Z Lu, LW Lim#. (2025) Past, present, and future of serotonin-targeting therapeutics for Alzheimer’s Disease: perspectives from DNA methylation. Ageing Research Reviews (5-year IF: 13; Rank: 3/74, top 3.4% in Geriatrics & Gerontology; In press)

  79. MWL Phang, NSM Hisam, F Supandi, PG Cheng, SH Lim, LW Lim#, KH Wong. (2025) Lignosus rhinocerotis medicinal mushroom mitigates oxidative damage in a cellular model mimicking Friedreich's ataxia. International Journal of Medicinal Mushrooms (5-year IF: 1.5; In press)

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Co-Authorship

  1. T Sesia, Y Temel, LW Lim, A Blokland, HWM Steinbusch, V Visser-Vandewalle. (2008) Deep brain stimulation of the nucleus accumbens core and shell: opposite effects on impulsive action. Experimental Neurology 214(1):135-9. (IF: 4.6)

  2. A Jahanshahi, R Vlamings, AH Kaya, LW Lim, S Tan, MLF Janssen, V Visser-Vandewalle, HWM Steinbusch, Y Temel. (2010) Hyperdopaminergic status in experimental Huntington disease. Journal of Neuropathology & Experimental Neurology 69(9):910-7. (IF: 3.2)

  3. T Sesia, S Tan, R Vlamings, LW Lim, V Visser-Vandewalle, Y Temel. (2008) Basal Ganglia and Behaviour: Behavioural effects of deep brain stimulation in experimental neuropsychiatry. Advances in Behavioral Biology 58:471-482. (Invited Review)

  4. S Tan, R Vlamings, LW Lim, T Sesia, M Janssen, HWM Steinbusch, V Visser-Vandewalle, Y Temel. (2010) Experimental deep brain stimulation in animal models. Neurosurgery 67(4):1073-80. (5-year IF: 4.1; Rank 25/290, top 8.4% in Surgery)

  5. Y Temel, S Tan, R Vlamings, T Sesia, LW Lim, V Visser-Vandewalle, C Baunez. (2009) Cognitive and limbic effects of deep brain stimulation in preclinical studies. Frontiers in Bioscience 14:1891-1901. (IF: 3.3)

  6. VMP Moers-Hornikx, T Sesia, K Basar, LW Lim, G Hoogland, HWM Steinbusch, DAWD Gavilanes, Y Temel, JSH. Vles (2009) Cerebellar nuclei are involved in impulsive behaviour. Behavioural Brain Research 5; 203(2):256-63. (IF: 2.6)

  7. T Sesia, K Basar, R Vlamings, LW Lim, Y Temel (2009) High frequency stimulation of the ventrolateral and mediodorsal thalamic nuclei: differential effects on impulsive action. Journal of Experimental Clinical Medicine 26(1):27-34. (IF: N.A.)

  8. AH Kaya, R Vlamings, S Tan, P Magill, LW Lim, H Steinbusch, V Visser-Vandewalle, T Sharp, Y Temel. (2008) Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats. Brain Research 1221:93-7. (IF: 2.7)

  9. P Andrade, L Noblesse, Y Temel, L Ackermans, LW Lim, HWM Steinbusch, V Visser-Vandewalle. (2010) Neurostimulatory and ablative treatment options in major depressive disorder: A systematic review. Acta Neurochirurgica (Wien) 152(4):565-77. (IF: 1.9)

  10. T Sesia, V Bulthuis, S Tan, LW Lim, R Vlamings, A Blokland, HWM Steinbusch, T Sharp, V Visser-Vandewalle, Y Temel. (2010) Deep brain stimulation of the nucleus accumbens shell increases impulsive behavior and tissue levels of dopamine and serotonin. Experimental Neurology 225(2):302-9. (IF: 4.6)

  11. E Kádár, LW Lim, G Carreras, D Genís, Y Temel, G Huguet. (2011) High-frequency stimulation of the ventrolateral thalamus regulates gene expression in hippocampus, motor cortex and caudate-putamen. Brain Research 1391:1-13. (IF: 2.7)

  12. SKH Tan, MLF Janssen, A Jahanshahi, L Chouliaras, V Visser-Vandewalle, LW Lim, HWM Steinbusch, T Sharp, Y Temel. (2011) High frequency stimulation of the subthalamic nucleus increases c-fos immunoreactivity in the dorsal raphe nucleus and afferent brain regions. Journal of Psychiatric Research 45(10):1307-15. (IF: 3.7)

  13. A Jahanshahi, Y Temel, LW Lim, G Hoogland, HWM Steinbusch. (2011) Close communication between the subependymal serotonergic plexus and the neurogenic subventricular zone. Journal of Chemical Neuroanatomy 42(4):297-303. (IF: 2.7)  

  14. VMP Moers-Hornikx, JH Vles, LW Lim, M Ayylidiz, S Kaplan, AWD Gavilanes, G Hoogland, HWM Steinbusch, Y Temel. (2011) Periaqueductal grey stimulation induced panic-like behaviour is accompanied by deactivation of the deep cerebellar nuclei. Cerebellum 10(1):61-69. (IF: 2.7)

  15. DH Zeef, R Vlamings, LW Lim, S Tan, ML Janssen, A Jahanshahi, G Hoogland, J Prickaerts, HW Steinbusch, Y Temel. (2012) Motor and non-motor behaviour in experimental Huntington’s disease. Behavioural Brain Research 226(2):435-9. (IF: 2.6)

  16. VMP Moers-Hornikx, JSH Vles, RJ Hemmes, LW Lim, G Hoogland, HWM Steinbusch, Y Temel. (2012) c-Fos expression in the deep cerebellar nuclei in a rat model of conditioned fear. Journal of Experimental Clinical Medicine 29:201-7. (IF: N.A.)

  17. S Hescham, LW Lim, A Jahanshahi, A Blokland, Y Temel. (2013) Deep brain stimulation in dementia-related disorders? Neuroscience and Biobehavioral Reviews 37:2666–2675. (5-year IF: 8.7; Rank: 3/55, top 4.8% in Behavioral Sciences)

  18. S Hesham, LW Lim, A Jahanshahi, HWM Steinbusch, A Blokland, Y Temel. (2013) Deep brain stimulation of the forniceal area enhances memory functions in experimental dementia: The role of stimulation parameters. Brain Stimulation 6(1):72-7. (5-year IF: 8.2; JCI Rank: 16/227, top 8.3% in Clin. Neurol.)

  19. D Tan, LJT Soh, LW Lim, D Tan, X Zhang, A Vyas. (2015) Infection of male rats with Toxoplasma gondii results in enhanced delay aversion and neural changes in the nucleus accumbens core. Proceedings of the Royal Society B: Biological Sciences 282(1808):20150042. (IF: 3.8)

  20. S Hescham, A Jahanshahi, C Meriaux, LW Lim, A Blokland, Y Temel. (2015) Behavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and anxiety-related functions. Behavioural Brain Research 292:353-60. (IF: 2.6)

  21. MS Yap, KR Nathan, Y Yeo, LW Lim, CL Poh, M Richards, WL Lim, I Othman, BC Heng. (2015) Neural differentiation of human pluripotent stem cells for nontherapeutic applications: toxicology, pharmacology, and in vitro disease modeling. Stem Cells International 2015:105172. (IF: 3.8)

  22. MS Yap, YQ Tang, Y Yeo, WL Lim, LW Lim, KO Tan, M Richards, I Othman, CL Poh, BC Heng. (2016) Pluripotent human embryonic stem cell derived neural lineages for in vitro modelling of enterovirus 71 infection and therapy. Virology Journal 13(1):5. (IF: 4)

  23. BC Heng, LW Lim, W Wu, CF Zhang. (2016) An overview of protocols for the neural induction of dental and oral stem cells in vitro. Tissue Engineering Part B: Reviews 22(3):220-250. (5-year IF: 8.9)

  24. BC Heng, T Gong, LW Lim, W Wu, CF Zhang. (2017) Decellularized matrix derived from neural differentiation of embryonic stem cells enhances the neurogenic potential of dental follicle stem cells Journal of Endodontics 43(3):409-416. (IF: 3.5)

  25. RW Chan, ATL Leong, CH Leon, P Gao, EC Wong, CM Dong, X Wang, J He, YS Chan, LW Lim, E Wu. (2017) Low-frequency hippocampal–cortical activity drives brain-wide resting-state functional MRI connectivity. Proceedings of the National Academy of Sciences of the USA 114(33): E6972-E6981. (5-year IF: 10.8; Rank: 13/134, top 9.3% in Multidisciplinary Sciences) [Featured in international media]

  26. BC Heng, T Gong, J Xu, LW Lim, C Zhang. (2018) EphrinB2 signalling modulates the neural differentiation of human dental pulp stem cells. Biomedical Reports 9(2):161-168. (IF: 2.3)

  27. Y Bhaskar, LW Lim, R Mitra. (2018) Enriched environment facilitates anxiolytic efficacy driven by deep-brain stimulation of medial prefrontal cortex. Frontiers in Behavioral Neuroscience 12:204. (IF: 2.6)

  28. BC Heng, B Yi, Shan Jiang, T Gong, H Chopra, LW Lim, C Zhang. (2019) Small molecules enhance neurogenic differentiation of dental-derived adult stem cells. Archives of Oral Biology 102:26-38. (IF: 2.2)

  29. Y Yeo, JBL Tan, LW Lim, KO Tan, BC Heng, WL Lim. (2019) Human embryonic stem cell-derived neural lineages as in vitro models for screening the neuroprotective properties of Lignosus rhinocerus (Cooke) ryvarden. BioMed Research International 3126376. (IF: 2.6)

  30. Dennison1, J Gao1, LW Lim, CJ Stagg, L Aquili. (2019) Catecholaminergic modulation of indices of cognitive flexibility: a pharmaco-tDCS study. Brain Stimulation 12(2):290-295. (5-year IF: 8.2; JCI Rank: 16/227, top 8.3% in Clin. Neurol.)

  31. C Borwick1, R Lal1, LW Lim, CJ Stagg, L Aquili. (2020) Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC. Brain Stimulation 13(1):105-108. (5-year IF: 8.2; JCI Rank: 16/227, top 8.3% in Clin. Neurol.)

  32. SY Lew, YY Yow, LW Lim, KH Wong. (2020) Antioxidant-mediated protective role of Hericium erinaceus (Bull.: Fr.) Pers. against oxidative damage in fibroblasts from Friedreich’s ataxia patient. Food Science and Technology 40(Suppl. 1): 264-272. (IF: 2.6)

  33. A Robson, LW Lim, L Aquili. (2020) Tyrosine negatively affects flexible-like behaviour under cognitively demanding conditions. Journal of Affective Disorders 260:329-333. (5-year IF: 5.4; Rank: 38/276, top 13.6% in Psychiatry)

  34. Z Leng, R Zhu, W Hou, Y Feng, Y Yang, Q Han, G Shan, F Meng, S Wang, J Fan, W Wang, L Deng, H Shi, H Li, Z Hu, F Zhang, J Gao, H Liu, X Li, Y Zhao, K Yin, X He, Z Gao, Y Wang, B Yang, R Jin, I Stambler, K Jin, LW Lim, H Su, A Moskalev, A Can, S Chakrabarti, A Keating, KJ Min, G Ellison-Hughes, C Caruso, RC Zhao. (2020) Transplantation of ACE2- mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia. Aging and Disease 11(2):216-228. (5-year IF: 7.1; Rank: 6/74, top 7.4% in Geriatrics & Gerontology) [Featured in international media]

  35. SY Lew, SH Lim, LW Lim, KH Wong. (2020) Neuroprotective effects of Hericium erinaceus (Bull.: Fr.) Pers. against high-dose corticosterone-induced oxidative stress in PC-12 cells. BMC Complementary Medicine and Therapies 20(1):340. (IF: 3.3)

  36. T Strekalova, E Svirin, E Veniaminova, E Kopeikina, T Veremeyko, AWY Yung, A Proshin, S Walitza, D Anthony, LW Lim, KP Lesch, ED Ponomarev. (2021) ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5. 16:100306. Brain, Behavior, & Immunity - Health 16:100306. (IF: 3.7)

  37. S Al-Janabi, LW Lim, L Aquili. (2021) Development of a tool to accurately predict UK REF funding allocation. Scientometrics 126:8049–8062. (IF: 3.5)

  38. K Subermaniam, SL Teoh, YY Yow, YQ Tang, LW Lim, KH Wong. (2021) Marine algae as emerging therapeutic alternatives for depression: A review. Iranian Journal of Basic Medical Sciences 24:1-17. (IF: 2.1)

  39. R Zhu, T Yan, Y Feng, Y Liu, H Cao, G Peng, Y Yang, Z Xu, J Liu, W Hou, X Wang, Z Li, L Deng, S Wang, J Li, Q Han, H Li, G Shan, Y Cao, X An,  J Yan, Z Zhang, H Li, X Qu, J Zhu, S Zhou, J Wang, F Zhang, J Gao, R Jin, D Xu, X Wang, H Cao, T Huang, Z Zheng, I Stambler, E Gilson, LW Lim, A Moskalev, A Cano, S Chakrabarti, B Ulfhake, H Su, HM Brown-Borg, K Min, G Ellison-Hughes, C Caruso, K Jin, Y Ma, RC Zhao. (2021) Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms. Cell Research 31:1244–1262. (IF: 36.4; Rank: 6/205, top 2.7% in Cell Biology)

  40. T Strekalova, E Veniaminova, E Svirin, E Kopeikina, T Veremeyko, AWY Yung, A Proshin, SZK Tan, S Khairuddin, LW Lim, KP Lesch, S Walitza, D Anthony, ED Ponomarev. (2021) Sex-specific ADHD-like behaviour, altered metabolic functions and altered EEG activity in sialyltransferase st3gal5-deficient mice. Biomolecules 11(12):1759. (IF: 4.8)

  41. M Prowacki, LW Lim, L Aquili. (2022) Eyeblink rate, a putative dopamine marker, predicts negative reinforcement learning by tDCS of the dlPFC. Brain Stimulation 15(3):533-535. (5-year IF: 8.2; JCI Rank: 16/227, top 8.3% in Clin. Neurol.)

  42. S Pak1, G Choi1, J Roy, CH Poon, M Lee, H Lee, D Cho, LW Lim, S Bao, S Yang, S Yang. (2022) Altered synaptic plasticity of the longitudinal dentate gyrus network in noise-induced anxiety. iScience.  25(5):104364. (IF: 4.6)

  43. K Caudwell, A Soranzo, LW Lim, L Aquili (2022) How have COVID-19 stringency measures changed scholarly activity? Annals of the New York Academy of Sciences 188:92-107. (5-year IF: 6.3)

  44. BC Heng, Y Bai, X Li, LW Lim, W Li, Z Ge, X Deng, X Zhang. (2023) Electroactive biomaterials for facilitating bone defect repair under pathological conditions. Advanced Science 10(2):2204502. (5-year IF: 16.3; Rank: 18/230, top 7.6% in Chem. Multidisciplinary)

  45. G Yatan, LW Lim, L Aquili. (2023) Routine behaviour, a putative dopamine marker, predicts cognitive flexibility by tDCS of the dlPFC. Brain Stimulation 16(1):108-110. (5-year IF: 8.2; JCI Rank: 16/227, top 8.3% in Clin. Neurol.)

  46. SK Agadagba, LW Lim, LLH Chan. (2023) Advances in transcorneal electrical stimulation: From the eye to the brain. Frontiers in Cellular Neuroscience 17: 1134857. (IF: 4.2)

  47. K Subermaniam, SY Lew, YY Yow, SH Lim, WS Yu, LW Lim, KH Wong. (2023) Malaysian brown macroalga Padina australis mitigates lipopolysaccharide-stimulated neuroinflammation in BV2 microglial cells. Iranian Journal of Basic Medical Sciences 26:669-679. (IF: 2.1) 

  48. KH Wong, LW Lim, NS Mohd Hisam, MNA Kamarudin, H Lakshmanan. (2023) Editorial: Natural products for neuroprotection and neuroregeneration. Frontiers in Pharmacology 14:1209297. (IF: 4.4)

  49. KM Caudwell, S Baldini, G Calvezzi, A Graham, K Jackson, I Johansson, M Sines, LW Lim, L Aquili. (2023) Learning bias predicts fear acquisition under stress but not cognitive flexibility. Physiology & Behavior 272:114384. (IF: 2.4)

  50. KY Nyiew, KH Wong, LW Lim, SH Lim, SM Phang, R Shyamala, YY Yow. (2024) Safety profile of subacute oral administration of ethanolic extract of Gracilaria manilaensis Yamamoto & Trono. Journal of Applied Phycology 36(4):2173-2182. (IF: 2.8)

  51. S Jiang, C Yuan, T Zou, J Koh, M Basabrain, Q Chen, J Liu, BC Heng, LW Lim, P Wang, C Zhang. (2024) An injectable hydrogel loaded with GMSCs-derived neural lineage cells promotes recovery after stroke. Tissue Engineering Part A 30(17-18):563-576. (IF: 3.5)

  52. AHB Chin, LW Lim, SM Muhsin. (2024) Regulatory safeguards needed if preimplantation genetic testing for polygenic risk scores (PGT-P) is permitted in Singapore. Journal of Medical Ethics 109195. (IF: 3.3)

  53. Buck, T Found, R Weldon, LW Lim, L Aquili. (2024) Dietary tyrosine consumption modulates the effects of tDCS, but not tRNS, on planning behaviour. Brain Stimulation 17(3):572-574. (5-year IF: 8.2; JCI Rank: 16/227, top 8.3% in Clin. Neurol.)

  54. M Nerush, V Shevyrin, N Golushko, A Moskalenko, LE Yang, D Galstyan, M de Abreu, D Rosemberg, LW Lim, K Demin, A Konstantin, A Kalueff. (2024)  Classics in chemical neuroscience: deliriant antihistaminic drugs.  ACS Chemical Neuroscience 15(21):3848-3862. (IF: 4.1)

  55. NP Ilyin, AD Shevlyakov, GA Boyko, AM Moskalenko, AN Ikrin, DS Galstyan, TO Kolesnikova, NV Katolikova, SA Chekrygin, LW Lim, L Yang, MS de Abreu, KB Yenkoyan, AV Kalueff, KA Demin. (2025) Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish. Brain Research 1848:149329. (IF: 2.7)

  56. DS Galstyan, NA Krotova, AS Lebedev, MM Kotova, DD Martynov, NI Golushko, AS Perederiy, IS Zhukov, DB Rosemberg, LW Lim, L Yang, MS de Abreu, RR Gainetdinov, AV Kalueff. (2025) Trace amine signaling in zebrafish models: CNS pharmacology, behavioral regulation and translational relevance. European Journal of Pharmacology 991:177312. (5-year IF: 4.3)

  57. J Jiang, Y Zhang, J Wang, Y Qin, C Zhao, K He, C Wang, Y Liu, H Feng, H Cai, S He, R Li, DS Galstyan, L Yang, LW Lim, MS de Abreu, AV Kalueff. (2025) Using zebrafish models to study epitranscriptomic regulation of CNS functions. Journal of Neurochemistry 169(1):e16311. (5-year IF: 4.9)

  58. N Erofeeva, DS Galstyan, L Yang, T Strekalova, LW Lim, MS de Abreu,  AV Kalueff. (2025) Developing zebrafish models of notch-related CNS pathologies. Neuroscience and Biobehavioral Reviews 170:106059. (5-year IF: 8.7)

  59. K Apukhtin, V Riga, M Kotova, L Yang, LW Lim, M Sander de Abreu, AV Kalueff. (2025) Neurobiology and neuropharmacology of zebrafish social behavior. Journal of Psychopharmacology (5-year IF: 4.5; In press)

  60. YH Kuang, W Zhu, G Lin, LM Cheng, Q Qin, ZJ Huang, YL Shi, CL Zhang, JH Xu, KX Yan, CZ Lv, W Li, Q Han, I Stambler, LW Lim, S Chakrabarti, B Ulfhake, KJ Min, G Ellison-Hughes, WC Cho, K Jin, D Yao, C Lu, RC Zhao, X Chen. (2025) Expert consensus on the application of stem cells in psoriasis research and clinical trials. Aging and Disease 16:3. (5-year IF: 7.1)